What is the pathophysiology of phosphatidylcholine toxicity?
Date:2023-02-09
Phosphatidylcholine (PC) is a major component of cell membranes and is involved in various cellular functions including signal transduction, intracellular membrane trafficking and lipid metabolism. PC toxicity can occur when phospholipases, enzymes located within the cell, breakdown PC to produce lysophosphatidylcholine (LPC). The LPC then enters the bloodstream and can accumulate in the liver, leading to hepatotoxicity, which has been linked to an increased risk of liver failure, liver cancer, and other organ damage. PC also has pro-inflammatory and pro-oxidative effects that can contribute to its toxicity. Additionally, PC has been linked to alterations in membrane dynamics, leading to neuronal injury and neurodegenerative diseases.
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