How does myosin bind to actin?

Date:2023-02-27
Myosin binds to actin via a “hit-and-run” mechanism. Myosin is composed of two heavy chains that have a binding head consisting of a regulatory light chain and a motor domain. When activated, the motor domain binds to the exposed binding sites on an actin filament. Once attached, myosin pulls the actin filament in a cycle of releasing, binding and contracting until equilibrium is reached and the muscle fiber relaxes.
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