What is the role of myosin light chain kinase in MLC phosphorylation?

Date:2023-02-18
Myosin light chain kinase (MLCK) is an enzyme that plays an integral role in MLC phosphorylation. When an action potential is transmitted down the cellular membrane to the muscle, it triggers a process known as "excitation-contraction coupling", in which calcium ions from the action potential are released from the muscle’s sarcoplasmic reticulum. This increase in intracellular calcium triggers MLCK, which catalyzes the phosphorylation of the myosin light chain protein. This phosphorylation leads to the myosin light chain setting up a molecular cross-bridge between the actin filaments and the myosin filaments, leading to the muscle contraction. Thus, MLCK is hugely important in this process, and plays the integral role of initiating contractions in the muscle cells.
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