What is the role of autophagy in the pathophysiology of bone loss?
Date:2023-01-06
Autophagy helps maintain bone mass by regulating the production of proteins involved in bone formation and remodeling, such as osteoprotegerin (OPG), osteocalcin (OCN), and receptor activator of nuclear factor-κB ligand (RANKL). Autophagy also plays a role in maintaining the stability of the bone microenvironment through the removal of senescent cells and apoptotic debris. Dysregulation of autophagy can lead to osteoporosis, a condition characterized by decreased bone mineral density, increased risk of fractures, and increased rate of bone turnover. In particular, decreased OPG and increased RANKL concentrations in the bone microenvironment have been linked to age-related bone loss and a high risk of fractures. Therefore, autophagy is an important part of the pathophysiology of bone loss, and it is important to ensure proper autophagic activity to maintain bone health.
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