What is the pathophysiology of lipid accumulation in atherosclerosis?

Date:2023-02-15
The pathophysiology of lipid accumulation in atherosclerosis is complex and not fully understood. It involves a variety of processes that begin with the deposition of low-density lipoprotein (LDL) cholesterol in the walls of arteries. This leads to the formation of fatty streaks, which are a precursor to more serious plaques. As fatty streaks accumulate, inflammatory cells and proteins are also attracted to the area, leading to the release of pro-inflammatory cytokines. This causes further damage to the artery wall, resulting in the formation of raised, hardened plaques. Over time, these plaques can further build up, narrowing the artery and leading to the possible complete obstruction of the vessel, which can cause serious and life-threatening complications such as stroke or heart attack.
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